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“If you’ve got ovaries the size of baseballs, sex is a much less appealing prospect.” The effect of semen on a woman’s immune system could also help explain why most couples do not fall pregnant straight away, says Robertson.This process may be important for allowing embryos to implant in the womb, rather than being rejected as a foreign body.In people, low regulatory T-cell counts are linked to several reproductive problems, including unexplained infertility, miscarriage, pre-eclampsia and pre-term labour.To use this website, cookies must be enabled in your browser.To enable cookies, follow the instructions for your browser below.Examining the cervix in women, the team found signs that semen does seem to prompt immune system changes in people too.

Shortly after sex, they detected the cervix begins to release immune signalling molecules, which may be an early sign of increased levels of regulatory T-cells.

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In mice, it seems to prime the female’s immune system for pregnancy, making it more likely that an embryo will successfully implant in the womb.

It appears to prompt similar changes in women, a finding that could explain why IVF is more successful if couples have regular sex during treatment.

Sarah Robertson at the University of Adelaide, Australia, and her colleagues found that each time a female mouse copulates, it caused the release of immune cells called regulatory T-cells, which are known to dampen down inflammation in the body.

“It’s as if the seminal fluid is a Trojan horse that activates the immune cells to get things ready for conception,” says Robertson.